By World Health Organization
This file provides the suggestions of the Subcommittee of the WHO specialist Committee liable for the WHO version checklist of crucial medicinal drugs. the duty of this Subcommittee used to be to attract up the 1st WHO version checklist of crucial medicinal drugs for kids. the 1st a part of the document encompasses a precis of the Committee’s concerns and justifications for the inclusion of specific medications within the version checklist for Children.Appendices to the most file contain the 1st WHO version checklist of crucial medicinal drugs for kids, an inventory of the entire goods it includes looked after in accordance with their 5-level Anatomical healing Chemical (ATC) class codes and a precis of medications to be reviewed earlier than the following assembly of the Subcommittee.
Read Online or Download The Selection and Use of Essential Medicines: Including the Model List of Essential Medicines for Children (WHO Technical Report Series) PDF
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This file provides the techniques of the Subcommittee of the WHO professional Committee accountable for the WHO version record of crucial drugs. the duty of this Subcommittee used to be to attract up the 1st WHO version checklist of crucial medications for kids. the 1st a part of the record includes a precis of the Committee’s issues and justifications for the inclusion of specific medicinal drugs within the version record for kids.
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Additional resources for The Selection and Use of Essential Medicines: Including the Model List of Essential Medicines for Children (WHO Technical Report Series)
In addition to the ﬁrst EML for children and a report of the Subcommittee deliberations, it is expected that the Subcommittee will make recommendations about dose forms, identify additional information needs and research gaps, and make recommendations about timelines and next steps to advance the agenda for better medicines for children. In response, Professor Cranswick, Dr Rodriguez, Dr Peterson, Professor Sachdev and Professor Jeena commented on the relationship between the existing EML and the EML for children.
The Expert Committee noted that no new substantive clinical evidence had been provided in support of the application since its previous review in March. It considered that three key questions remain unanswered: • Is the dose of artemether as proposed in the preparation effective? e. a loading dose followed by a lower maintenance dose)? • Can therapeutic equivalence be accepted on the assumption that since both drugs are metabolized to the same active principle, equal doses of the separate parent compounds give identical clinical effect?
The group was unable to recommend a standard pathway for conducting speciﬁc types of studies at the present time. It therefore recommended that speciﬁc diseases and/or medicines be used to develop these approaches, 32 and that as TB, malaria and neglected tropical diseases had been identiﬁed as priority questions for the EMLc, these could be used as the initial examples. Education and capacity building The group acknowledged the need to disseminate more widely, detailed information on appropriate study designs and on the relative merits of the different approaches to evaluating the effectiveness and safety of medicines.