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Additional info for Modified Nucleosides: in Biochemistry, Biotechnology and Medicine
20 mM). NOEs between ligand 1 and several amino acids of Bcl-xL, A104, L108 and L130, could also be identiﬁed. 7b) . 7 The Bcl-xL protein [13, 14]. (a) Typical high-affinity ligands, 1 and 2. (b) NMR structure of the Bcl-xL protein in complex with 40 -fluoro-1,10 -biphenyl-4-carboxylic acid 3 (orange) and 5,6,7,8-tetrahydronaphthalen-1-ol 4 (orange). The phenylalanine residue 97 at the binding site is highlighted in red (PDB ID 1YSG) . structural data obtained from 19 F NMR experiments were in good accordance with the known high-resolution structure of Bcl-xL and highly similar ligands, indicating that ﬂuorine labeling can yield structural information additional to data obtained from traditional 13 C- and 15 N-labeling.
Recently, this approach has beneﬁted from current technical advances, such as the introduction of 19 F cryoprobes . 9 Schematic of the 3-Fluorine Atoms for Biochemical Screening (3-FABS) approach for screening enzyme inhibitors. (a) The principle of 3-FABS screening. (b) Multiple enzyme reactions can be screened using the 3-FABS approach [16, 17]. 2 19 F NMR Spectroscopy of Nucleic Acids As described above, 19 F NMR spectroscopy not only provides important contributions towards the elucidation of protein structures and dynamics, but also contributes to the ﬁeld of nucleic acids, where the number of interesting 19 F NMR spectroscopic approaches is currently increasing.
Cotten, M. , Isolation characterization of two 5-ﬂuorouracil-substituted Escherichia coli initiator methionine transfer ribonucleic acids. Biochemistry 1983, 22, 1113–1122. 25 Chu, W. , Liu, J. , Localization of the major ethidium bromide binding site on tRNA. Nucleic Acids Res. 1997, 25, 3944–3949. , Correlations between ﬂuorine-19 nuclear magnetic resonance chemical shift and the secondary and tertiary structure of 5-ﬂuorouracil-substituted tRNA. J. Mol. Biol. 1992, 227, 1173–1181. , Derrick, W.