Download e-book for kindle: Modified Nucleosides: in Biochemistry, Biotechnology and by Piet Herdewijn

By Piet Herdewijn

Edited by means of one of many major riding forces in the back of the field's momentous upward push lately, this one-stop reference is the 1st complete source to combine contemporary advances.
the 1st half addresses biochemical elements and functions, the second one and 3rd elements are dedicated to compounds with healing capability, with the 3rd half targeting newly brought anticancer nucleoside drugs.
crucial analyzing for each scientist operating during this quarter.

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20 mM). NOEs between ligand 1 and several amino acids of Bcl-xL, A104, L108 and L130, could also be identified. 7b) [13]. 7 The Bcl-xL protein [13, 14]. (a) Typical high-affinity ligands, 1 and 2. (b) NMR structure of the Bcl-xL protein in complex with 40 -fluoro-1,10 -biphenyl-4-carboxylic acid 3 (orange) and 5,6,7,8-tetrahydronaphthalen-1-ol 4 (orange). The phenylalanine residue 97 at the binding site is highlighted in red (PDB ID 1YSG) [14]. structural data obtained from 19 F NMR experiments were in good accordance with the known high-resolution structure of Bcl-xL and highly similar ligands, indicating that fluorine labeling can yield structural information additional to data obtained from traditional 13 C- and 15 N-labeling.

Recently, this approach has benefited from current technical advances, such as the introduction of 19 F cryoprobes [15]. 9 Schematic of the “3-Fluorine Atoms for Biochemical Screening” (3-FABS) approach for screening enzyme inhibitors. (a) The principle of 3-FABS screening. (b) Multiple enzyme reactions can be screened using the 3-FABS approach [16, 17]. 2 19 F NMR Spectroscopy of Nucleic Acids As described above, 19 F NMR spectroscopy not only provides important contributions towards the elucidation of protein structures and dynamics, but also contributes to the field of nucleic acids, where the number of interesting 19 F NMR spectroscopic approaches is currently increasing.

Cotten, M. , Isolation characterization of two 5-fluorouracil-substituted Escherichia coli initiator methionine transfer ribonucleic acids. Biochemistry 1983, 22, 1113–1122. 25 Chu, W. , Liu, J. , Localization of the major ethidium bromide binding site on tRNA. Nucleic Acids Res. 1997, 25, 3944–3949. , Correlations between fluorine-19 nuclear magnetic resonance chemical shift and the secondary and tertiary structure of 5-fluorouracil-substituted tRNA. J. Mol. Biol. 1992, 227, 1173–1181. , Derrick, W.

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