By Stefan Faderl, Hagop Kantarjian
Edited through specialists from one of many world’s biggest leukemia facilities, this booklet presents details at the biology of the diversity of leukemic problems, up to date diagnostic trying out and lots of new advancements in remedy. Chapters overlaying new remedies current an outlook for the long run and clarify the reason for ongoing medical trials.
- Targeted remedy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, package inhibitors, BCR-ABL inhibitors)
- Ras inhibitors
- Epigenetic treatment (hypomethylaters and histone deacetylase inhibitors)
- Lenalidomide analogs
- New chemotherapy medications, e.g. clofarabine, cloretazine, sapacitabine, forodesine
- Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols together with dasatinib or imatinib)
- New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40)
- Thrombopoietic agents
Leukemias: rules and perform of Therapy
- Includes useful details to lead you in difficult occasions, akin to remedy of aged sufferers, being pregnant, relapsed and refractory disease
- Incorporates chapters on supportive care and pharmacologic information regarding the main usually used medicinal drugs during this area
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Additional info for Leukemias: Principles and Practice of Therapy
Occup Environ Med 1998;55:230–5. Metayer C, Johnson ES, Rice JC. Nested case–control study of tumors of the hemopoietic and lymphatic systems among workers in the meat industry. Am J Epidemiol 1998;147: 727–38. Hayes RB, Blair A, Stewart PA, Herrick RF, Mahar H. S. embalmers and funeral directors. Am J Ind Med 1990; 18:641–52. Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH. Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia 2008;22:240–8. Schoch C, Kern W, Kohlmann A, Hiddemann W, Schnittger S, Haferlach T.
56 Doody MM, Mandel JS, Lubin JH, Boice JD, Jr. Mortality among United States radiologic technologists, 1926–90. Cancer Causes Control 1998;9:67–75. 57 Cardis E, Gilbert ES, Carpenter L, et al. Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res 1995;142:117–32. 58 Weiss HA, Darby SC, Fearn T, Doll R. Leukemia mortality after X-ray treatment for ankylosing spondylitis. Radiat Res 1995;142:1–11. 59 Inskip PD, Monson RR, Wagoner JK, et al.
Ionizing radiation Cases of MDS are reported in cohorts of people exposed to radiation, either for treatment of diseases such as ankylosing spondylitis  or following exposure to the atomic bomb in Hiroshima and Nagasaki . Mauritzson et al. identified a longer latency period for the development of t-MDS/AML following radiotherapy exposure (median 207 months) compared with alkylating agent chemotherapy plus or minus radiotherapy (median 63 months) . The incidence of t-MDS/AML 19 does not appear to be increased following local radiotherapy for lymphoma, but is probably increased following total body irradiation exposure at autologous stem-cell transplant .