Lars Kaestner's Calcium signalling: Approaches and Findings in the Heart and PDF

By Lars Kaestner

The e-book combines common suggestions and strategies to enquire calcium signalling in cells starting from molecular biology ways to manipulation of calcium in residing cells. the point of interest inside those equipment in at the huge diversity of fluorescence imaging expertise, particularly on optical sectioning ideas and quick photo acquisition. as well as those normal directions there are software examples in a context past calcium signalling in significant fields: investigations of remoted cardiac myocytes and purple blood mobile comparable learn. whereas the mobile cardiology part offers snapshots of yes calcium signalling facets, the pink blood phone half provides an outline from the useful id of calcium-channels to an idea of physiological and pathophysiological relevance.

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Extra resources for Calcium signalling: Approaches and Findings in the Heart and Blood

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Wang, Y. & Chien, K. R. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation 101, 178–184 (2000). , Quadt-Humme, S. & Hallek, M. Recent developments in adeno-associated virus vector technology. The journal of gene medicine 10, 717–733 (2008). , Lipp, P. & Bernhardt, I. Prostaglandin E2 activates channel-mediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process. Thrombosis and Haemostasis 92, 1269–1272 (2004).

This finding establishes aggregation as the intended functional readout of calcium signalling. Aggregation is traditionally measured either by microscopic investigation by quantifying a microscopic aggregation index97 or by indirect methods that measure properties from red blood cell suspensions as a liquid. Such techniques include sedimentation-associated procedures, light-interacting readouts, measurements of viscosity and other rheometric methods95. However, when it comes to adhesion force measurements rheometric techniques have widely been used98,99.

Development of an aequorin luminescence calcium assay for high-throughput screening using a plate reader, the LumiLux. Assay Drug Dev Technol 6, 787–793 (2008). [61] Webb, S. , Rogers, K. , Karplus, E. & Miller, A. L. The use of aequorins to record and visualize Ca(2+) dynamics: from subcellular microdomains to whole organisms. Methods in cell biology 99, 263–300 (2010). [62] Cohn, W. E. & Cohn, E. T. Permeability of red corpuscles of the dog to sodium ion. Proc. Soc. Exp. Biol. Med. 41, 445–449 (1939).

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