By Thomas Ming Swi Chang
This can be a accomplished and primary type assessment of approximately all vital and basic advancements of artifiical cells by means of the nestor of this department in utilized biomedial technological know-how himself. This "bible" is vital analyzing for either novices and the skilled expert. Chang wrote an outstanding and stimulating assessment over 50 years of synthetic mobile examine and improvement and purposes.
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Extra resources for Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine)
This means that smaller molecules can move across 10 ml of 20 µm diameter artiﬁcial cells 100 times faster than that across an artiﬁcial kidney machine (Chang, 1966). The microscopic size of artiﬁcial cells also allows material to diffuse rapidly inside the artiﬁcial cells. (3) Artiﬁcial cells can contain the same biological material as biological cells. In addition, they are more versatile since adsorbents, magnetic materials, cells, drugs and other material can also be included separately or in combination (Fig.
1965). Mueller and Rudin (1968) adopted the Chang procedure for the preparation of artiﬁcial cells (Chang, 1964) to prepare artiﬁcial cells having only a single bilayer lipid membrane. Since biological cell membranes consist of both protein and lipids, we ch02 FA April 2, 2007 12:8 SPI-B446 Artiﬁcial Cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative... Artiﬁcial Cells 28 have prepared artiﬁcial cells with membrane of lipid-polymer or lipid-protein for membrane transport studies (Chang, 1969d).
2002). Multienzyme systems with cofactor recycling Most enzymes in the body function as multienzyme systems with cofactor recycling. After basic research on artiﬁcial cells containing multienzyme systems (Chang, 1985a), we looked into their possible use. 3). The needed cofactor, NADH, can be recycled and retained inside the artiﬁcial cells by crosslinking to dextran or by using a lipid-polymer membrane. , 2003) (Fig. 3). ch02 FA April 2, 2007 12:8 SPI-B446 Artiﬁcial Cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative...