New PDF release: Antiangiogenic Agents in Cancer Therapy (Cancer Drug

By Beverly A. Teicher

Beverly Teicher and a panel of wonderful investigators survey the cutting-edge of antiangiogenesis learn from the lab bench to medical trials. well timed and authoritative, the participants summarize our present knowing of tumor development and its dependence on vascular improvement, in addition to the current prestige of antiangiogenic brokers in preclinical and medical improvement. furthermore, the ebook additionally examines what's recognized concerning the mechanisms through which those healing brokers intrude with tumor vasculature and grapples with the matter of building standards during which to evaluate their scientific efficacy. Antiangiogenic brokers in melanoma treatment deals a different state of the art compendium of antiangiogenic examine, taking inventory of what has been entire , the place the experimental therapeutics of antiangiogenic brokers goes, and the ongoing evolution in their position in melanoma therapy and novel drug improvement.

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05). Very low values (<2 mmHg) represented 20% of the recorded values before treatment and 10% after 2 wk, and low pO2 values (<10 mmHg) accounted for, respectively, 45% and 25% of the recorded values. An increase in median pO2 was shown in nine tumors on 14, a decrease in 4, and no changes in one. For the nine tumors with values recorded below 2 mmHg, a decrease in the percentage of very low values (increased oxygenation) was found in seven cases after 2 wk of treatment. 4. CARBOGEN BREATHING One efficient way to decrease the percentage of low pO2 values in tumors is to breathe carbogen, or pure oxygen, throughout every radiotherapy fraction (63–65).

28. Young, W. , and Wardman, P. (1996) Measurement of oxygen tension in tumours by time-resolved fluorescence. Br. J. Cancer 74(Suppl. XXVII), S256–S259. 29. Olive, P. , Viske, C. , and Durand, R. E. (1994) Hypoxic fractions measured in murine tumors and normal tissues using the comet assay. Int. J. Radiat. Oncol. Biol. Phys. 29, 487–491. 30. Urtasun, R. , Parliament, M. , McEwan, A. , Mercer, J. , Mannan, R. , Wiebe, L. , and Chapman, J. D. (1996) Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside.

Natl. Acad. Sci. USA 922, 4606–4610. 29. , and Hombach, V. (1996) Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation 94, 1647–1654. 30. , and Claffey, K. (1997) Hypoxia regulates the expression of VPF/VEGF and its receptors in human skin. J. Inves. Dermatol. 108, 263–268. Chapter 1 / Oxygen Transport in Solid Tumors 19 31. , et al. (1994) Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J. Clin. Invest. 93, 1564–1570.

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