Download PDF by C K Cain: Annual Reports in Medicinal Chemistry, 4

By C K Cain

ANNUAL experiences IN MED CHEMISTRY V4 PPR.

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Claussen and F. Korte, Psychopharmacologia, 5, 332 (1968). 149. B. X. , 2, 267 (1968). 150. " Report by the Advisory Committee on Drug Dependence, HM. ,. London (1968) 151. T. E. Zinberg and J. H. Nelsen, Science, l62, 1234 (1968). 152. C. B. id. B. Richards, Arch. I n t . Pharmacodyn. , 625 (l%8). N. C. b) idem, West Ind. Ned. , 232 (1968). 154. M. E. Himich, Nature, 220, 491 (1968). 155. T. Uyeno, J. Pharmacol. Exp. , l59, 216 (1968). 156. E. Bindler, I. Sanghvi and S. Gershon, Arch. Int. Pharmacodyn.

Leff and S. Bernstein, Dis. Nerv. , 29, 621 (1968). 137. 13s. 139. 140. 141. 142. 143. 1, E968). , 111, 2, 2, z, 1, 2, 2, 2, 3, 146, 5, 204, Chapter 3. Sedatives, Hypnotics, Anticonvulsants Muscle Relaxants, General Anesthetics Carl D. Lunsford, A. H. , Richmond, V i r g i n i a - Introduction Following t h e format o f previous e d i t i o n s o f t h i s chapter the discussion o f compounds i s d i v i d e d on the basis o f e s t a b l i s h e d o r p r o j e c t e d c l i n i c a l use and t o a l e s s e r e x t e n t on the basis o f pharmacol o g i c a l p r o p e r t i e s r a t h e r than on t h e basis o f chemical s t r u c t u r e .

Low doses may cause p e r i p h e r a l v a s o d i l a t i o n only, while higher doses a l s o decrease c a r d i a c o u t p u t . Excessive doses re$uce c a r d i a c o u t p u t without changing p e r i p h e r a l r e s i s t a n c e . * I n cases of poor cont r o l w i t h ST 155 a l o n e , combination w i t h methyldopa o r guanethidine gave good r e s u l t s without o r t h o s t a t i c o r r e n a l problems ? - Methyldopa Strong evidence f o r a c e n t r a l mechanism of a c t i o n w a s r e p o r t e d t 6 Pretreatment w i t h R0-4-4602, (N1-DLseryl-N-2,3,4-trihydroxybenzylhydrazine) a c e n t r a l and peri p h e r a l decarboxylase i n h i b i t o r , completely i n h i b i t e d t h e 48 - Sect.

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