By Wojciech Gorczyca
This large reference masking neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors concerning lymph nodes, spleen, bone marrow, and in most cases affected extranodal organs, with distinctive emphasis at the differential analysis. It discusses simple medical, prognostic, morphologic and phenotypic information, with a number of tables summarizing the phenotypic profiles of the commonest hematologic tumors. a huge characteristic of this ebook is an method of hematologic tumors in response to the WHO class, with proper examples and emphasis at the most valuable morphologic and immunophenotypic beneficial properties utilized in diagnosis.It might be a useful reference for all working towards hematologists, oncologists and pathologists.
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Extra resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
Flow cytometry immunophenotyping shows no loss of pan-T antigen expression (D–G). Lack of aberrant expression of pan-T antigens does no exclude malignancy. g. CD33 or CD117. 9 presents a comparison between the mature and precursor T-cell neoplasms. TALL/LBL more often shows dimmer expression of CD45, lack of CD2 and CD3 (surface), dual positive or dual negative CD4/CD8 expression, lack of TCR, and expression of CD10 and CD117 when compared to mature tumors20,22. 19 Flow cytometry immunophenotyping—CD4:CD8 ratio.
Bright expression of CD11c is seen in HCL. Moderate expression of CD11c is observed in a subset of B-CLL/SLL, marginal zone B-cell lymphoma and occasional DLBCL. CD19 is positive in B-cell lymphomas and is negative in plasma cell neoplasms (~6% are CD19+). Most B-cell lymphomas display moderate expression of CD19, although FL may show dim CD19. Dim CD20 expression Introduction 27 is typical for B-CLL/SLL, and bright CD20 is observed in HCL. Other B-cell lymphoproliferations show moderate CD20. Coexpression of CD5 and CD23 is most typical for B-CLL/SLL.
Typical (moderate-bright) expression of all four antigens is present in 32% of peripheral (mature) T-cell lymphomas, most commonly in T-prolymphocytic leukemia (T-PLL; 57%), followed by AILD (25%), Sezary’s syndrome (12%), anaplastic large cell lymphoma (11%), T-LGL (8%), and peripheral T-cell lymphoma, unspecified (7%). Therefore, lack of abnormal pan-T antigen expression does not exclude malignancy. 18 presents T-PLL in the bone marrow (A) with clonal T-cells (PCR analysis; B), CD4 restriction (C) and normal expression of all four pan-T markers (D–G).