New PDF release: Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia

By Andrew Hadley, Peter Soothill

The potent prevention, prognosis, and administration of alloimmune cytopenias has turn into a workforce attempt concerning hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and learn scientists. This ebook has been written by means of specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, analysis, and medical administration. This entire yet obtainable account is widely cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among analysis and healing intervention.

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Extra info for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

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Plasmapheresis in Rh hemolytic disease, the danger of amniocentesis. International Journal of Artificial Organs, 6, 83–6. 12 Viëtor HE, Kanhai HHH & Brand A (1994). Induction of additional red cell alloantibodies after intrauterine transfusions. Transfusion, 34, 970–4. 13 Murray S (1957). The effect of Rh genotypes on severity in haemolytic disease of the newborn. British Journal of Haematology, 3, 143–52. 14 Rochna E & Hughes-Jones NC (1965). The use of purified 125I-labelled anti-␥ globulin in the determination of the number of D antigen sites on red cells of different phenotypes.

Plasmapheresis in Rh hemolytic disease, the danger of amniocentesis. International Journal of Artificial Organs, 6, 83–6. 12 Viëtor HE, Kanhai HHH & Brand A (1994). Induction of additional red cell alloantibodies after intrauterine transfusions. Transfusion, 34, 970–4. 13 Murray S (1957). The effect of Rh genotypes on severity in haemolytic disease of the newborn. British Journal of Haematology, 3, 143–52. 14 Rochna E & Hughes-Jones NC (1965). The use of purified 125I-labelled anti-␥ globulin in the determination of the number of D antigen sites on red cells of different phenotypes.

49 The relevance of these observations to the pathogenesis of HDFN is not yet established. 45 The longer hinge region of IgG3 may confer to the molecule the ability to span the gap between negatively charged red cells and monocytes with greater efficiency than IgG1. Although an association between IgG subclass and the extent of haemolysis in utero might be expected, studies using predominantly serological techniques have generated conflicting results. 52,58 The application of quantitative techniques should resolve these inconsistent results.

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