Download e-book for kindle: Aging and Life-Prolonging Processes by Prof. Dr. Vladimir Veniaminovich Frolkis (auth.)

By Prof. Dr. Vladimir Veniaminovich Frolkis (auth.)

There is an Inca incantation which acknowledged stated approximately: "Lord, provide me religious peace in order that i will be able to acquiesce to what i can't switch, supply me braveness in order that i will switch what i will swap, and provides me knowledge in order that i will be able to distinguish one from the opposite. " evidently, this incantation might be frequently repeated through any gerontologist, because it is especially tricky to tell apart getting older from the approaches which complement the organism's viability, getting older from ailments, and the mechanisms of getting older in a variety of species of animals. based on N. surprise, who compiled a priceless bibliography of the works on getting older, greater than 43,000 works on gerontology were released within the final decade. Why can we proceed to disagree with each other and carry that crucial mechanisms are nonetheless principally unknown to us regardless of that stream of data and an incredible variety of proof? what's it that we don't comprehend? might it's that we don't comprehend the only sacramental truth that can clarify every thing, resembling the hormone of getting older, the programmed triggering of a suicide gene, the looks of a different poisonous agent within the axoplasmic movement of gear, and so on? Goethe as soon as wrote scientist regularly holds convinced components, yet regrettably he lacks their sacred link.

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It is an important problem not only in gerontology, but also in medicine as a whole. Enough facts are now known to maintain that the organism's adaptive possibilities are curtailed in the aging process. Consequently, vulnerable spots are engendered in its self-regulation system and the prerequisites are created for Aging and Diseases 31 some diseases. Diseases cannot be regarded as aging processes proper, just as aging cannot be identified with diseases. The organism's biological properties sharply change during ontogeny, starting from the zygote to very old age.

Every stage of ontogeny has its own level of adaptation and its own age characteristics of the organism's metabolism, structure and function. All this qualitatively, or fundamentally, distinguishes every stage of the organism's development in its reactions to an environmental change. These qualitative features of development largely determine the specifics of age pathology, i. e. the disappearance or growth of definite diseases with age and a change in the specifics of the occurrence of the same pathology during different age periods.

It is enough to recall the substantial shifts in mentality, i. e. in higher nervous activity, or the fact that the more perfect form of energy generation, namely, oxidative phosphorylation, suffers earlier in the aging process, while the more ancient form, namely, glycolysis, is even activated in some tissues. But this does not mean that changes always occur in this direction as the organism ages. In many cases, the evolutionary more ancient mechanisms age sooner than the mechanisms which originated later and are more pedect.

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