Get Acute Leukemias IX: Basic Research, Experimental Approaches PDF

By T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. med. Wolfgang Hiddemann, Prof. Dr. Dr. med. phil. Torsten Haferlach, Dr. med. Michael Unterhalt, Prof. Dr. med. Thomas Büchner, Prof. Dr. med. Jörg Ritter (eds.)

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6 Miyamoto T et al. (2000) AMLl/ETOexpressing nonleukemic stem cells in acute myelogenous leukemia with 8;21chromosomal translocation. Proc Nat! Acad Sci USA 97(13):7521-6 Miyamoto T et al. (2000) AMLl/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Nat! Acad Sci USA 97(13):7521-6 Okuda T et al. (1998) Expression of a knocked-in AMLl-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

In (A) the open boxes are regions of homology between ETO and the Drosophila homologue of ETO termed Nervy: TAFllO, a domain with homology to the Drosophila TAF 11 0 protein; HHR, hydrophobic heptad repeat; ND, nervy domain; ZF, zinc finger. HDAe, histone deacetylase. DBD, DNA binding domain. SMMHe, smooth muscle myosin heavy chain. 2. (A) Schematic diagram of the t(8;21) fusion protein and its molecular contacts with the N-CoR and mSin3 co-repressors and histone deacetylases. Open boxes are regions of homology with the Drosophila homologue of ETO termed Nervy.

Several cytokines (IL-4, TGF-~1, TNF-u, TNFP) had significant inhibitory effects. The immunoglobulin heavy chain gene was found to be rearranged. Giemsa-banding cytogenetics showed the following karyotype which was identical in all three sister cell lines: 4S<2n>X, -Y, t(12;13)(p12;q13-14). The karyotype and DNA fingerprinting confirmed the malignant nature and the authenticity of the cell line, excluding cross-contamination with other cells. MUTZ-S represents a new unique leukemia B-celliine; its scientific significance lies in the t(12;13).

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