New PDF release: 5-HT4 Receptors in the Brain and Periphery

By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This e-book offers a complete, up to date overview of the distribution, pharmacology and body structure of primary 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes show a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been the most intensively studied in recent times, either from a easy examine point of view and as a aim for novel therapeutics.

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Additional resources for 5-HT4 Receptors in the Brain and Periphery

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Hegde SS, Moy TM, Perry M et al. Evidence for the involvement of 5-HT4 receptors in 5- hydroxytryptophan-induced diarrhea in mice. J Pharmacol Exp Ther 1994; 271:741-747. 21. Villalon CM, Den Boer MO, Heligers JP et al. Further characterization, by the use of tryptamine and benzamide derivatives, of the putative 5-HT 4 receptor mediating tachycardia in the pig. Br J Pharmacol 1991; 102:107-112. 44 s-HT4 Receptors in the Brain and Periphery 22. Eglen RM, Alvarez R, Johnson LG et al. The action of SDZ 205,557 at 5-hydroxytrypamine (5-HT3 and 5-HT4 ) receptors.

4'22 This is not surprising since the amino acid sequences of these two clones are identical, apart from the cytoplasmic carboxy tail, a region that is important for G-protein-coupling. In functional assays measuring cAMP release, transiently expressed 5-HT4s and 5-HT4L receptors exhibited very similar pharmacological profiles. Some differences were noted; in general, the potency of agonists for stimulating cAMP release was greater for 5-HT4s receptor. os). os). os) despite the lower expression levels.

2. 3· 4· 5· 6. Dumuis A, Bouhelal R, Sebben M et al. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol Pharmacol 1988; 34:880-887. Dumuis A, Bouhelal R. Sebben Metal. A 5-HT receptor in the central nervous system positively coupled to adenylate cyclase is antagonized by ICS 205-930. Eur J Pharmacol 1988; 146:187-188. Bockaert J, Fozard JR, Dumuis A et al. The 5-HT4 receptor: a place in the sun. Trends Pharmacol Sci 1992; 13:141-145.

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